Oxalacetic acid, 2- -, ethyl

Oxal-ither, oxalic ether (ethyl oxalate), -essigester, m. oxalacetic ester, -essigsaure, /, oxalacetic acid, -ester, m, oxalic ester (specif, ethyt oxalate),... 

Ethyl dnnamate occurs in small amounts in storax.1 It has been prepared by the action of ethyl alcohol on cinnamic acid in the presence of dry hydrochloric or sulfuric acid 2 by the distillation of the copper salt of the monoethyl ester of benzylidene oxalacetic acid 3 and by the condensation of ethyl acetate and benzaldehyde in the presence of sodium.4 The method described in the procedure is a slight modification of the one originally described by Claisen.5... 

This acetylpyridone diester 15 was conveniently synthesized in 60% yield by reacting acetoacetamide with ethoxy-methylene oxalacetic acid diethyl ester 14 in ethanol in the presence of sodium acetate (13). Compound 14 was prepared according to the procedure of R. G. Jones by condensing ethyl oxalacetate with ethyl orthoformate in the presence of acetic anhydride (14). It was found that purified compound 14 gave the best yield (60%) of acetylpyridone diester 15, but as a matter of convenience, crude 14 gave product 15 in up to 40% yield. Isolation of 15 was expedited by the precipitation of its sodium salt from the reaction mixture. 

The method of synthesis described for chloropyruvic acid is essentially that reported. This procedure affords the product in excellent yields from readily available materials by a short, convenient route. Other less acceptable methods involve chlorination of pyruvic acid with sulfur dichloride or hypochlorous acid and the treatment of ethyl chloro(l-hydroxyheptyl)- or (o -hydroxybenzyl)oxalacetate 7-lactone with 50% hydrochloric acid. ... 

The three-component reaction of sodium ethyl oxalacetate with ammonia or primary amines with an aromatic aldehyde in ethanol or acetic acid results in the... 

These syntlieses give no indication as to the structure of aspartic acid, the constitutional formula of which is based upon Kolbe s work, that it is amino-succinic acid the only synthesis of aspartic acid which confirms this constitution appears to be that by Piutti in 1887. Sodium oxalacetic ester, prepared from oxalic ester and acetic ester in the presence of sodium ethylate —... 

Method of manufacture phenylhydrazine p-sulfonic acid is condensed with sodium ethyl oxalacetate the product obtained from this reaction is then coupled with diazotized sulfanilic acid. 

A route to hept-2-ulosonic acid derivatives is available by way of the reaction of 2,3 4,5-di-0-isopropylidene-L-arabinose and 2,4 3,5-di-0-ethylidene-L-xylose with ethyl nitrosoacetate. ° Isomerization of the intermediate nitroso derivatives with alcoholic sodium nitrite yielded the corresponding oximes, which can be deoximated with lead tetra-acetate in acetic acid. 3-Deoxy-D-manno-oct-2-ulosonic acid 5-(dihydrogen phosphate) and its D-gluco analogue have been obtained by base-catalysed condensation of o-arabinose 2-phosphate (obtained by way of phosphorylation of benzyl 3,4-0-isopropylidene-P-D-arabinopyrano-side) with oxalacetic and separation of the isomers by ion-exchange chromato-graphy. ... 

A soln. of 4-amino-3-hydroxy-5-methylacetophenone and the equivalent amount of diethyl oxalacetate refluxed 1 hr. ethyl 5-methyl-7-acetylbenz-l,4-oxazin-2-on-3-ylacetate. Y ca. 90%.—Because these benz-l,4-oxazin-2-ones crystallize well and can be cleaved by alkali, they are suitable for the separation of aminophenols and the identification of the o-isomers. Even isomeric o-aminophenols can be separated due to different reaction rates. F. e. s. A. Butenandt, E. Biekert, et al., B. 92, 2172 (1959). Condensed l,4-oxazin-2-ones may also be used for the identification of a-ketocarboxylic acid esters. E. s. B.94, 1664 (1961). 

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