Oxacillin Methotrexate

Clinically important, potentially hazardous interactions with amoxicillin, ampicillin, antacids, bacampicillin, calcium carbonate, carbenicillin, cloxacillin, digoxin, methotrexate, methoxyflurane, mezlocillin, nafcillin, oxacillin, penicillins, piperacillin, ticarcillin, zinc... 

Clinically important, potentially hazardous interactions with acitretin, aluminum hydroxide, amoxicillin, ampicillin, antacids, bacampicillin, betamethasone, bismuth, bromelain, calcium, carbenicillin, cholestyramine, doxacillin, corticosteroids, dairy products, dicloxacillin, didanosine, digoxin, food, glidazide, iron, isotretinoin, methicillin, methotrexate, methoxyflurane, mezlocillin, nafcillin, oxacillin, penicillins, piperacillin, retinoids, rocuronium, strontium ranelate, sucralfate, ticarcillin, vitamin A, zinc... 

Reduced clearance and acute methotrexate toxicity has been attributed to the concurrent use of various penicillins (amoxicillin, benzylpenicillin, carbenicillin, dicloxacillin, flucloxacillin, mezlocillin, oxacillin, penicillin, phenoxymethylpenicillin, piperacillin, ticarcillin) in a small number of case reports. 

Intravenous infusion 15 g over 6 hours Oxacillin (1 g every 8 hours starting 6 hours after methotrexate infusion) Osteogenic sarcoma (1) Rasma methotrexate levels 53-fold higher than in previous cycles without oxacillin fatal acute toxicity (renal failure and aplastic anaemia) 5... 

Titier K, Lagrange F, Pehourcq E, Moore N, Molimard M. Pharmacokinetic interaction between high-dose methotrexate and oxacillin. Then Drug Monit (2002) 24, 570-2. 

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See also in sourсe #XX -- [ ]

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