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Overview of Oxidatively Generated DNA Damage

Major progress has been achieved during the last two decades in achieving a better understanding of the degradation pathways of the bases and 2-deoxyribose moieties of isolated DNA and related model compounds upon exposure to 02, OH, one-electron oxidants, and HOC1. Extensive model studies have led to the isolation [Pg.53]

The Chemical Biology of DNA Damage. Edited by Nicholas E. Geacintov and Suse Broyde 2010 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 978-3-527-32295-4 [Pg.53]


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