Over-expressed receptors

Peptide/receptor Amino acids Tumors over expressing receptor... 

S100A1 is the most abundant in the myocardium but is also expressed in brain and other tissues. S100A1 was found to stimulate Ca2+-induced Ca2+-release (CICR) in skeletal muscle terminal cisternae. In the presence of nanomolar Ca2+-concentrations, S100A1 binds to the ryanodine receptor increasing its channel open probability, and was shown to enhance SR Ca2+-release and contractile performance. Several animal models (over expressing S100A1 or S100A1-deficient mice) have... 

White, T. L. and Youngentob, S. L. The effect of NMDA-NR2B receptor subunit over-expression on olfactory memory task performance in the mouse. Brain Res. 1021,1-7, 2004. 

HSC and progenitor cells after radiation exposure have the self-renewal capacity needed for leukemia induction. This was shown at low, intermediate and high dose intervals. Cells in patients as compared to controls more often expressed anti-apoptotic protein Bcl-2 and less often demonstrated expression of Fas receptor (fig. 6-7). Cells in patients with low CD8-h counts were simultaneously Fas negative and Bcl-2 positive in 4 out of 19 studied patients. We assume that cells over-expressing anti-apoptotic protein Bcl-2 and demonstrating low Fas expression could lack apoptotic response to environmental factors. 

An increase in the nnmber of receptors in the membrane of the tumour cells (i.e. over-expression of the gene) allows the receptors to respond to low concentrations of growth factor. (See chapter 12 for discnssion of hormone receptors and response to hormones.)... 

Trastuzumab (Herceptin) [Antineeplastic/Monoover express the HERlIneu. protein breast CA adjuvant, w/ doxorubicin, cyclophosphamide, and paclitaxel if pt HER2/neu(+) Action MoAb binds human EGF receptor 2 protein HER2) mediates cellular cytotox Dose Per protocol, typical 2 mg/kg/IV/wk Caution [B, ] CV dysfxn, alla-gy/inf Rxns Contra Live vaccines Disp Inj SE Anemia, cardiomyopathy, nephrotic synd, pneumonitis Interactions t Risk of cardiac dysfxn W/ anthracycline, cyclophosphamide, doxorubicin, epirubicin EMS Cardiomyopathy, ventricular dysfxn and pulm tox have been reported monitor for Sxs of reduced cardiac Fxn OD Sxs unknown... 

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