Ovarian cancer INDEX

Alberts DS, Green S, Hannigan EV, et al. Improved therapeutic index of carboplatin plus cyclophosphamide versus cisplatin plus cyclophosphamide Final report by the Southwest Oncology Group of a phase 111 randomized trial in stages III and IV ovarian cancer [published erratum appears in J Clin Oncol 1992 10 1505]. J Clin Oncol 1992 10 706-717. 

Cleveland Clinic. (2008). Menopause and Ovarian Cancer. Cleveland Clinic Center for Consumer Health Information. Available at http //www.clevelandclinic.org/health/healthinfo/docs/3000/3009. asp index=10111. Accessed January 19, 2009. 

Engeland, A., Tretli, S., andBjorge, T., Height, body mass index, and ovarian cancer a followup of 1.1 million Norwegian women, J. Natl Cancer Inst., 95,1244,2003. 

Lurtotecan (GL147211C, 7-[(4-methylpiperazine)methyl]-10,l l-(ethylenedioxy)-CPT, 13) is another example of water-soluble, synthetic derivative of CPT bearing a dioxalane moiety between C-10 and C-11 [28-30, 278], The antitumor activity of lurtotecan in Phase II trial was moderate in breast cancer patients and minimal in nrai-small-cell lung cancer patients, and no clear responses were obtained in colorectal patients [278], Better results were observed with the use of liposomal lurtotecan formulation. Such prepared drug exhibited superior levels of activity and higher therapeutic index in prechnical models [279, 280], Its clinical activity has also been confirmed in treatment of epithelial ovarian cancer [28],... 

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