Ovarian cancer chemoprevention

Justify the risk and benefits of the surgical and chemoprevention options available for decreasing the potential risk of developing ovarian cancer. 

Many of the hop s constituents, including valerianic acid, have a sedative effect, and it is now used to treat insomnia, restlessness, and anxiety. Its bitter principals, humulon and lupulon, are gastrointestinal stimulants used to treat indigestion and loss of appetite. These bitter acids also have antibacterial and antimicrobial properties. The hop is believed to contain chemicals that promote menstruation, and certain flavonoids have shown potential chemopreventive activity against breast and ovarian cancer. 

Chan, M.M., Fong, D., Soprano, K.J., Hohnes, W.F., and Heverhng, H., Inhibition of growth and sensitization to cisplatin-mediated killing of ovarian cancer cells by polyphenohc chemopreventive agents, . Cell. Physiol, 194 (1), 63-70, 2003. 

The prenylflavonoids of hops, including xanthohumol, have displayed antiproliferative antitumor activities against a number of human cancer cell lines, such as prostate, breast, ovarian, and colon cancers. Induction of apoptosis and inhibition of NF-kB may be involved in the antitumor activity. Cancer chemopreventive activities of the prenylflavonoids have also been reported. ... 

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