Our Series 22 Patients

In our series of 308 patients, 158 proved to have invasive pelvic neoplasms. As described in Section 3,4,3, fewer than 1.4% of healthy adult females have serum Mn-SOD levels above 130 ng/ml. Only 7 of the 39 patients (17.9%) with benign ovarian tumors had Mn-SOD levels exceeding 130 ng/ml. In the nonovarian gynecological malignancies group, 9 out of 40 patients (22.5%) with uterine cervical cancer and 8 of 40 patients (20.0%) with endometrial cancer had Mn-SOD levels above 130 ng/ml (Table 5). 

In our own series of patients, which has been reviewed by Louis (1972), the drugs responsible were pyrazolone analgesics in 22 cases, barbiturates in 19, sulfonamides in five, phenolphthalein in three, tetracyclines in two, benzodiazepines in two, and a hydantoin derivative in one case. Other causes of fixed eruptions have been observed by Loveman (1943), Brehm and Brehm (1963), and Post and Dougherty (1964). 

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