Otoacoustic distortion product

In a placebo-controUed study in 123 patients with colorectal polyps and normal hearing at frequencies of 250-2000 Hz, efiornithine 0.075-0.4 g/m /day for 12 months had no effect on auditory pure-tone thresholds or distortion product otoacoustic emission (14). There was no hearing loss, in contrast to studies with higher dosages. 

The ototoxicity of cisplatin has been studied using distortion-product otoacoustic emissions (DPOAEs) and conventional pure-tone audiometry (151). Cisplatin ototoxicity was detected on average one cycle earlier with DPOAEs than with pure-tone audiometry. The authors suggested that this was because DPOAEs are more sensitive to outer hair cell damage. 

Ozturan O, Jerger J, Lew H, Lynch GR. Monitoring of cisplatin ototoxicity by distortion-product otoacoustic emissions. Auris Nasus Larynx 1996 23 147-51. 

Janssen T, Boege P, Oestreicher E, Arnold W. Tinnitus and 2fl-f2 distortion product otoacoustic emissions following salicylate overdose. J Acoust Soc Am 2000 107(3) 1790-2. 

List of Abbreviations ACh, acetylcholine DPOAE, distortion product otoacoustic emission IHCs, inner hair cells MET, mechanoelectric transducel NEC, nonlinear capacitance OHCs, outer hair cells PFAE, promyclocytic leukemia zinc finger protein RC, resistance and capacitance SEC, solute-carrier family SSC, sub-surface cistern... 

Age-related loss of distortion product otoacoustic emissions in four mouse strains. Hear Res 138 91-105. 

Lonsbury-Martin BL, Martin GK. 1990. The clinical utility of distortion-product otoacoustic emissions. Ear Hear 11 144-154. 

Distortion product otoacoustic emissions (DPOAEs) can be used to evaluate the function of the outer hair cells alone. DPOAEs are created as a by-product of outer hair cell motility following a specific stimulus presentation. When the basilar membrane moves in response to a sound, outer hair cells are stimulated and by electromotility aid in tuning specific frequencies to stimulate the inner hair cells... 

Dalhoff E, Turcanu D, Zeimer H, Gummer A (2007) Distortion product otoacoustic emissions measured as vibration on the eardrum of human subjects. Proc Natl Acad Sci USA 104 (5) 1546-1551. doi 10.1073/pnas.0610185103... 

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