Distortion product otoacoustic emissions DPOAEs

The ototoxicity of cisplatin has been studied using distortion-product otoacoustic emissions (DPOAEs) and conventional pure-tone audiometry (151). Cisplatin ototoxicity was detected on average one cycle earlier with DPOAEs than with pure-tone audiometry. The authors suggested that this was because DPOAEs are more sensitive to outer hair cell damage. 

Distortion product otoacoustic emissions (DPOAEs) can be used to evaluate the function of the outer hair cells alone. DPOAEs are created as a by-product of outer hair cell motility following a specific stimulus presentation. When the basilar membrane moves in response to a sound, outer hair cells are stimulated and by electromotility aid in tuning specific frequencies to stimulate the inner hair cells... 

List of Abbreviations ACh, acetylcholine DPOAE, distortion product otoacoustic emission IHCs, inner hair cells MET, mechanoelectric transducel NEC, nonlinear capacitance OHCs, outer hair cells PFAE, promyclocytic leukemia zinc finger protein RC, resistance and capacitance SEC, solute-carrier family SSC, sub-surface cistern... 

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