Other Viruses That May Utilize Mechanisms Similar to Poliovirus

OTHER VIRUSES THAT MAY UTILIZE MECHANISMS SIMILAR TO POLIOVIRUS 

Many lytic viruses, other than picornaviruses, markedly inhibit host cell protein synthesis during the course of the infectious cycle. None have been investigated to the same extent as poliovirus with respect to the mechanism of this function. However, there are a few preliminary studies which might be interpreted as indications of similar effects on initiation factor activity. 

Both of the above analyses were conducted on cells infected with the Bearing strain of reovirus, type 3. Sharpe and Fields (1982) showed that type 2 reovirus inhibits cellular protein synthesis more effectively than type 3. By isolating recombinant viruses containing various combinations of double-stranded RNA segments derived from both strains of reovirus, they demonstrated that the S4 RNA segment, which encodes the major outer capsid protein of the virion, is responsible for the ability of type 2 reovirus to inhibit L cell ma-cromolecular synthesis. Inactivation of type 2 reovirus by ultraviolet 

---