Other Biological Roles of Trehalose

Protein stabilization by trehalose in aqueous solution is also an example of the biological functions of trehalose [84-86]. According to reports by Timasheff and coworkers, preferential hydration should occur when the interaction of a cosolvent with water is stronger than its interaction with a protein [85]. In other words, a water structure maker like trehalose is a good cosolvent causing 

The physicochemical uniqueness of trehalose originates from the presence of an a, a-1,1-linkage, which brings about the rigid conformation with a clam, shell-like shape. Because of the conformational rigidity, trehalose has a 

This work was supported in part by the Program for Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN) and also in part by Grants-in-Aid for Scientific Research on Priority Areas (no. 16041212 and 18031012) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. 

Kurose, M. Kubota, S. Fukuda, M. Kurimoto, Y. Tujisaka, M. Sakurai, Nippon Shokuhin Kagaku Kougaku Kaishi (in Japanese) 50, 133 (2003) 

Sola-Penna, J.R. Meyer-Fernandes, Arch. Biochem. Biophys. 360, 10 (1998) 

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