Osteoclast-like giant cells

Immunohistochemical studies of these tumors have focused mainly on the nature of their constituent mononuclear-stromal and multinucleate giant cells. The osteoclast-like giant cells usually stain strongly for however, mononuclear elements label... 

Undifferentiated Carcinoma with Osteoclast-like Giant Cells... 

These neoplasms often have TP53 gene mutations, and immunolabeling for the p53 protein has been shown to label the pleomorphic mononuclear cells but not the osteoclast-like giant cells. Additionally, genetic analyses have demonstrated that the atypical mononuclear cells harbor KRAS mutations in about 90% of these... 

S-100 and vimentin. However, some cells of the sarcomatous component also retain keratin in some cases. " Spindle cell carcinomas may also have osteoclast-like giant cells, in which case the osteoclast-like giant cells express histiocytic differentiation markers. ... 

Molberg KH, Heffess C, Delgado R, et al. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region. Cancer. 1998 82 1279-1287. 

Sakai Y, Kupelioglu AA, Yanagisawa A, et al. Origin of giant cells in osteoclast-like giant cell tumors of the pancreas. Hum Pathol. 2000 31 1223-1229. 

Shiozawa M, Imada T, Ishiwa N, et al. Osteoclast-like giant cell tumor of the pancreas. Int J Clin Oncol. 2002 7 376-380. 

Sasaki A, Yokoyama S, Nakayama I, et al. Sarcomatoid hepatocellular carcinoma with osteoclast-like giant cells case report and immunohistochemical observations. Pathol Int. 1997 47 318-324. 

Deckard-Janatpour K, Kragel S, Teplitz RL, et al. Tumors of the pancreas with osteoclast-like and pleomorphic giant cells an immunohistochemical and ploidy study. Arch Pathol Lab Med. 1998 122 266-272. 

HA has a Ca P ratio of 1.67 which is similar to bone mineral. It can be prepared by sintering of precipitated Ca-P salts in a Ca P ratio of 1.67 at temperatures above 1000°C. Pure HA is hardly soluble under physiological conditions. Impurities like substitution of Ca + by other metal ions cause variation in solubility and crystal size due to the differences in ionic radius. With respect to mechanical strength, pure HA materials are superior to other Ca-P materials. In vivo, however, pure HA hardly shows any cellular resorption by macrophages, giant cells or osteoclasts unless the particle size is small enough for phagocytosis. As a consequence, HA should be considered as nonresorbable whereas other compositions such as P-TCP show substantial dissolution and resorption. 

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