Orphenadrine interaction

Atropine interacts with antipsychotics, antihistamines, phenothiazines, and antidepressant drugs. Benzhexol, orphenadrine, and oxybutynin hydrochloride are drugs of potential abuse poisoning and withdrawal symptoms are reported.150... 

Interactions the sedative effects of antidepressants, anxiolytics and hypnotics are likely to be enhanced by antihistamines, as are the antimuscarinic actions and side-effects of drugs such as trihexyphenidyl, orphenadrine, tricyclic antidepressants and phenothiazines. 

Potential interactions between bupropion and orphenadrine (affected by CYP2B6) may be expected. 

Methylbenzhydrol is prepared by the interaction of 2-methyl benzaldehyde and phenyl magnesium bromide, which on chlorination with thionyl chloride yields the 2-methyl benzhydryl chloride. The resulting product is then eonverted to the amino ether by reaetion with dimethylamino ethanol. The orphenadrine (base) is eaused to reaet, in an appropriate solvent, with an equimolar quantity of citric acid to form the offieial eompound. 

Drugs that affect metaboiism by CYP2B6 (e.g., orphenadrine and cyciophosphamide) aiso have the potentiai to interact with bupropion. 

Pearson RE, Salter FJ. Drug interaction — Orphenadrine with propojqfphene. NEnglJMed... 

An alleged adverse interaction between dextropropoxyphene and orphenadrine, which is said to cause mental confusion, anxiety, and tremors, seems to be very rare, if indeed it ever occurs. 

Loga S, Curry S, Lader M. Interactions of orphenadrine and phenobaibitone with chlorpro-mazine plasma concentrations and effects in man. BrJ Clin Pharmacol (1975) 2,197-208. 

---