Organosilicon compounds synthesis

P. F, Hudrlik, Organosilicon compounds in organic synthesis, J. Organometal. Chem. Library 1, 127 (1976). 

Peroxy Compounds of Transition Metals J. A. Connor and E. A. V. Ebsworth The Direct Synthesis of Organosilicon Compounds J. J. Zuckerman... 

Organosilicon compounds are widely used in our daily life as oil, grease, rubbers, cosmetics, medicinal chemicals, etc. However, these compounds are not naturally occurring substances but artificially produced ones (for reviews of organosilicon chemistry, see [59-64]). Hydrosilylation reactions catalyzed by a transition-metal catalyst are one of the most powerful tools for the synthesis of organosilicon compounds. Reaction of an unsaturated C-C bond such as alkynes or alkenes with hydrosilane affords a vinyl- or alkylsilane, respectively (Scheme 16). 

Since the silanone intermediates have been postulated as key intermediates in reports on the synthesis and reactions of organosilicon compounds,27 the isolation of a stable silanone and its characterization should be one of the most fascinating subjects in the future chemistry of low-coordinate organosilicon compounds. 

So far only a few examples of the uses of organosilicon compounds in cross-couplings have been published. Noteworthy is the smooth reaction with a sterically hindered substrate (87).295 The synthesis of the alkaloid nitidine included a cross-coupling step using an alkenylsilane (88),296 while the syntheses of some antitumor agents involved the alkenylation of unprotected iodouracyls using alkenyl-silicon species.297... 

It is hoped that the examples and the accompanying mechanistic discussions of electrochemical reactions of organosilicon compounds shown in this review will provide a guide to the potential utility of such reactions in organic synthesis and to the development of new electroorganic chemistry based on the unique properties of silicon. 

Herzog, U. Organosilicon Halides - Synthesis and Properties. In The Chemistry of Organic Silicon Compounds Rappoport, Z., Apeloig, Y., Eds. ... 

During the last three decades, a number of organosilicon compounds have been prepared which have opened new vistas in the synthesis of numerous organic compounds and have brought to light many fascinating reactions. 

EXPEDITED ORGANIC SYNTHESIS WITH ORGANOSILICON COMPOUNDS... 

SOME APPLICATIONS OF ORGANOSILICON COMPOUNDS TO ORGANIC SYNTHESIS... 

Recently organosilicon compounds are being used for the synthesis of olefines by elimination reactions both in acidic and basic conditions. Thus P hydroxysilanes give defines. These reactions have been shown to be highly stereospecific. The acid catalysed elimination taking place by an anti pathway and the base induced elimination taking place by a syn pathway. 

Expedited Organic Synthesis with Organosilicon Compounds Creation of a Bond Protection of Groups Activation... 

Some Applications of Organosilicon Compounds to Organic Synthesis Why Silicon Compounds are Reactive... 

Organosilicon compounds are widely used in organic synthesis. The understanding of the structure and properties of the intermediates involved in their reactions is a prerequisite for further development and optimization of useful synthetic transformations involving silicon substituted compounds. Trialky lsilyl-substituted carbocations are particularly... 

This chapter describes the application of iridium-catalyzed reactions in the synthesis of molecular and macromolecular organosilicon compounds and related sihcon derivatives. Some mechanistic implications are introduced which illustrate the specific catalytic activation of organic and silicon compounds by iridium... 

Organosilicon compounds (continued) synthesis of in electric discharges, 6 165-167... 

Hydrosilylation, the addition of a silicon-hydrogen bond to multiple bonds, is a valuable laboratory and industrial process in the synthesis of organosilicon compounds. The addition to carbon-carbon multiple bonds can be accomplished as a radical process initiated by ultraviolet (UV) light, y irradiation, or peroxides. Since the discovery in the 1950s that chloroplatinic acid is a good catalyst to promote the addition, metal-catalyzed transformations have become the commonly used hydrosi-... 

Two new mechanisms have been suggested to account for the observation. Dehydrogenative silylation has become a useful method for the synthesis of unsaturated organosilicon compounds.611,614... 

Synthesis and biological investigation of organosilicon compounds, having analogous sila-substituted structures of organic compounds with well known bioactivity (- sila-pharmaca). 

During the following years investigations in the field of organosilicon compounds were concentrated on the development of new methods of synthesis of silatranes and on the study of their steric and electronic structure, various physical properties and, especially, their biological activity2-15 ... 

The last ten years have experienced a great advance in the synthesis of novel and unusual organosilicon compounds which are interesting in view of their structure or relevance to theory. 29Si NMR study of such interesting and unusual compounds will be treated in this section. 

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