Organoplatinum complexes

Carboplatin (96) is significantly less toxic in the clinic than cisplatin. Most particularly, it is much less nephrotoxic. Use of a bidentate ligand also ensures formation of a ds complex. Its synthesis begins with cis-diammine platinum diiodide (94) which is reacted with silver sulfate to give cis-diaquodiam mine platinum sulfate (95). This is reacted with the barium salt of 1,1-cyclo-butanedicarboxylic acid to yield carboplatin [23], 

Spiroplatin (99) in animal studies showed excellent antileukemic activity and was less 

The only prominent antitumor tetravalent platinum complex so far is iproplatin (102). In vitro it has been shown to cause interstrand DNA-breaking and cross linking. Free radical scavengers inhibit these effects. The complex is less neurotoxic and less nephrotoxic than cisplatin. Its synthesis begins with hydrogen peroxide oxidation of cis-dichlorobis(isopropvlamine) platinum (100) to the dimethylacetamide complex 101. The latter is heated in vacuum to liberate iproplatin [25]. 

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Figure Bl.25.2 shows the XPS spectra of two organoplatinum complexes which contain different amounts of chlorine. The spectrum shows the peaks of all elements expected from the compounds, the Pt 4f and 4d doublets (the 4f doublet is iimesolved due to the low energy resolution employed for broad energy range scans). Cl 2p and Cl 2s, N Is and C Is. Flowever, the C Is caimot be taken as characteristic for the complex only. All surfaces that have not been cleaned by sputtermg or oxidation in the XPS spectrometer contain carbon. The reason is that adsorbed hydrocarbons from the atmosphere give the optimum lowering of the surface free energy and hence, all surfaces are covered by hydrocarbon fragments [9].

A. Klein, E.J.L. Mclnnes, T. Scheiring and S. Zalis, Electronic structure of radical anionic binuclear organoplatinum complexes. A multiple frequency EPR investigation, J. Chem. Soc., Faraday Trans., 1998, 94, 2979. 

Figure 3.4 XPS scans between 0 and 450 eV of two organoplatinum complexes showing peaks due to Pt, Cl, N and C. The C 1 s signal not only represents carbon in the compound but also contaminant hydrocarbon fragments, as on any sample. The abbreviation Me in the structures stands for CH3 (courtesy of J.C. Muijsers, Eindhoven).

Ofloxacin, 141,142,144,145 Ofomine, 102 Olsalazine, 42 Olvanil, 35 Omeprazole, 133 Oral antidiabetic agent, 3 Oral contraceptives, 66, 68 Orange crush, 62 Organoplatinum complexes, 15 Oxagrelate, 151,152 Oxaprotiline, 63 Oxendolone, 66 Oximonam, 195... 

Binuclear Organoplatinum Complexes as Models for Catalytic Intermediates... 

Figure 3.4 illustrates the use of Eq. (3-3) in an example on organoplatinum complexes. The sample for XPS analysis was prepared by allowing a solution of the complexes in dichloromethane to dry on a stainless steel sample stub. The sample should thus be homogeneous, and the use of Eq. (3-3) permitted. The... 

In 1986, it was reported that organoplatinum complexes based on the monoanionic terdentate ligand [C6H3(CH2NMe2)2-2,6]-, abbreviated as NCN, reversibly... 

Organic Synthesis and Catalysis Involving Organoplatinum Complexes... 

Organoplatinum complexes have a strong resemblance to the palladium analogs in their synthetic methodology and reaction patterns, but because of their high stability. 

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