Organophosphorus nerve agent acetylcholinesterase inhibition

All what applies to CW agents is basically also true for toxic industrial compounds (TIC) like pesticides, etc. Organophosphorus pesticides are used extensively to control agricultural pests. Similary to nerve agents, they inhibit the enzyme acetylcholinesterase (AChE) [8]. Expositions mainly might occur in pesticide production plants and dnring their application in forestry, agriculture, and horticulture. Chemically similar compounds are used as flexibilizers or additives in lubrication solvents. 

Mercey, G., Verdelet, T., Renou, J., et ah, 2012a. Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. Acc. Chem. Res. 45,... 

Nerve agents are organophosphorus (OP) compounds that inhibit acetylcholinesterase (AChE) extremely rapidly, which results in an accumulation of acetylcholine (ACh), leads to muscle fasciculations and paralysis, and finally results in death (Dacre, 1984). There are several strategies available to verify an exposure to nerve agents. It is not... 

Toxicity The agents GA, GB, and VX are rapidly acting, lethal nerve agents. They directly affect the nervous system and are toxic as liquids and vapors. They are organophosphorus esters that inhibit acetylcholinesterase, an enzyme that prevents the accumulation of the neurotransmitter acetylcholine at the nerve synapses. When too much acetylcholine is present, convulsion and death may result. 

G-series nerve agents. This series of iionpersistent nerve agents includes tabun. sarin, soman, and GF. They are organophosphorus compounds that inhibit action of a key nervous system enzyme (acetylcholinesterase). 

---