Organophosphorus dichlorides

Some diastereoselectivity was also observed in the reaction of (S)-prolinol with the dichloride (257) leading to the chiral organophosphorus compounds (258). 

In different years, Russian toxicologists implemented into practice antidotic agents for medical aid to those affected with high toxic organophosphorus poisonous substance (PS), such as aphin, dipiroxime, budaxim. The studies have been completed on development and implementation into industrial production of an antidote for self-care and mutual aid, pelixime, as well as a ChR, carboxime (l-4-methyl-5-[21-(benzyl dimethyl ammonium) ethyl]) carbamoilpyridinium-2-aldoxime dichloride [88, 89],... 

Dimethylphenylphosphine is a ligand commonly used to prepare a large range of transition metal-organophosphorus complexes. This basic phosphine is easy to handle and presents a small cone angle.1,2 It is usually prepared in 40-50% yield by reaction of a solution of methylmagnesium halide with phenylphosphonous dichloride followed by hydrolysis with an excess of saturated aqueous ammonium chloride solution.3 4 In the present preparation the yield has been greatly increased (to 85%). 

The synthesis of phosphorus (V) anhydrides of form 9 through condensation of organophosphorus (V) dichlorides with salts of organic acids is reported in this chapter. This is considered an extension of previous work by Carraher and others, regarding condensations using water sensitive acid... 

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