Organophosphorus compounds introduction

Although several chemicals, e.g. arsenicals and organophosphorus compounds, had been used with some effect to treat specific helminth infections, the introduction in 1930 of phenothiazine (1) was a revolutionary event in the control of gastrointestinal worms. Although its spectrum of activity was narrow compared to modern anthelmintics and its dose level was rather high (600-800 mg kg-1), it was the veterinary anthelmintic of choice until the 1960s. 

GAI calculation has been demonstrated for dimethyl methylphosphonate and has been applied to quantitative structure-density correlations for organophosphorus compounds [30]. For an introduction to other quantum-chemical indices, the review of Balasubramanian [31] should be consulted. Ab initio descriptors used in the GIPF approach (see Section 1.5) have been discussed by Murray, et al. [32]. 

Chiral organophosphorus compounds have been found to act as catalysts in numerous enan-tioselective reactions. This review highlights recent developments in this area and more precisely in the kinetic resolution of secondary alcohols, the enantioselective borane reduction of ketones, and in the asymmetric C-C bond formation with the introduction of asymmetric two-center catalysts. 

INTRODUCTION TO THE SYNTHESIS OF ORGANOPHOSPHORUS COMPOUNDS GENERATED THROUGH THE FORMATION OF PHOSPHORUS-CARBON BONDS... 

There has also been a voltammetric study for the anodic oxidation of amino-substituted phosphaalkenes (APA) of the class of compound with C2p-P3p)n bonding, and composition Ph-P=C(R)-NR2. For the first APA wave, the half-wave potential (E0 values are the lowest found so far of all organophosphorus compounds, pointing strongly to anodic oxidation of the phosphaalkene fragment, and leading to wide possibilities for the introduction of intermediate species into the subsequent chemical and electrochemical reactions with different substrates. 

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