Organocatalytic Oxidation. Ketone-Catalyzed Asymmetric Epoxidation of Alkenes and Synthetic Applications

Organocatalytic Oxidation. Ketone-Catalyzed Asymmetric Epoxidation of Alkenes and Synthetic Applications 

Trans and trisubstituted aikenes conjugated with aromatic groups appear to be more effective substrates, likely because of the large size of aromatic substituents, thus providing more efficient stereodifferentiation. A number of chiral ketones can provide good to high ccs for this class of aikenes (Table 3.1). However, trans and 

Fructose-derived ketone 42 has been shown to be a highly general ketone catalyst (typically 20-30 mol% used) for epoxidation of a wide variety of trans and trisubsti- 

Like ketone 44a, these N-aryl-substituted ketones have also been found to be highly effective for a variety of alkenes, including cis-P-methylstyrenes [24f], chromenes 

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