ORGANIC AND INORGANIC MASS SPECTROMETRY

Xiang, X., Ko, C. Y., and Guh, H. Y., Ion-exchange chromatography/ electrospray mass spectrometry for the identification of organic and inorganic species in topiramate tablets, Anal. Chem., 68, 3726, 1996. 

Van Vaeck, L. Struyf, H. Van Roy, W. Adams, F. Organic and inorganic analysis with laser microprobe mass spectrometry. Mass Spectrom Rev. 1994,13,189-208. 

Most compounds can be detected directly as they are able to produce a direct analytical signal. Photometric detection, especially UV (including diode array and multi-wavelength UV detection) is by far the most frequently applied detection technique. The application of mass spectrometry (MS) detection in CE is attractive as it can provide structural information [44]. Hologram-based refractive index detection [45] and electrochemical detection [46,47] were also reported. Conductivity [41,48-50] and amperometric [51,52] detection has shown to have advantages for the analysis of both organic and inorganic compounds. 

Analytical techniques such as liquid chromatography/mass spectrometry (LC/ MS) to evaluate nonvolatile organics, gas chromatography/mass spectrometry (GC/ MS) to evaluate semivolatile organics, and inductively coupled plasma (ICP) spectroscopy to detect and quantitate inorganic elements should be a part of this study. 

Mass spectrometry is a standard spectroscopic technique for the characterisation of high molecular weight organic and inorganic compounds, but has until recently received little attention from the zeolite community. The surface composition of zeolites has been explored using fast atom bombardment mass spectrometry (FABMS)[66] and secondary ion mass spectrometry [67], but mass spectrometric analysis of the bulk composition of a zeolite or of adsorbed molecules has not until very recently been attempted. The practical difficulty is to vaporise the solid. Two different strategies have been proposed laser ablation and plasma desorption. 

Carre V, Aubriet F, Scheepers PT, Krier G, MuUer JF. Potential of laser ablation and laser desorption mass spectrometry to characterize organic and inorganic environmental pollutants on dust particles. Rapid Com mu n Mass Spectrom 2005 19 871-80 [Epub ahead of print]. 

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