Organ-specific effect

Organ-spcctfic Defining organ-specific effects and defining chemically induced critical effects... 

Randerath K, Putman KL, Randerath E, et al. 1988. Organ-specific effects of long-term feeding... 

Horak, E., Darling, D. L. and Turin, D. (1986). Analysis of organ- specific effects on metastatic tumor formation by studies in vitro. J. Natl. Cancer Inst. 75,... 

Sheth-Desai N, Lamba-Kanwal V, Eichholz A. 1987. Organ-specific effects of 1,2-dimethylhydrazine in hamster. Jpn J Cancer Res 78 117-125. 

Despite these general considerations, until now the unusual diversity of symptoms observed after the uptake of an overdose in the intact organism could not be explained adequately. The effects of an overdose of heavy metals manifest themselves in very different tissues, partially with a rather high specificity for certain metals and their compounds. These organ-specific effects could not yet be explained. 

Data reported by Dontenwill and Mohr (15A09) indicated that NDEA had an organ-specific effect in the tracheobronchial tree of hamsters. 

Jarry, H., S. Leonhardt, C. Duls, et al. 1999. Organ-specific effects of Cimicifuga racemosa in brain and uterus (abstract). Paper read at 23rd International LOF-Symposium on Phyto-Oestrogens, at University of Gent, Belgium. 

Although chronic tests can be conducted to evaluate only target-organ specific effects (e.g., kidney damage), they are generally conducted to evaluate either cancer, reproductive, or developmental effects. The testing methods and features specific to these are discussed in the following sections. 

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