Organ culture systems, tissue interaction media

The cell culture analog (CCA) system is one approach attempting to narrow this gap. It is developed to address the issues of reactive metabolite formation and tissue-tissue interaction through exchange of metabolites or signal molecules, and to evaluate potential efficacy and toxicity of pharmaceuticals and environmental chemicals. A CCA device can be considered as a simplified and minimized human/animal body, in which mammalian cell cultures are used to represent key functions of specific organs, and cell culture medium is used as a blood surrogate. 

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