Orap

Crap (Janssen-Cilag) Orap (Janssen-Cilag) Orap (Janssen-Cilag)... 

Pimozide (Orap). Pimozide is probably the most potent of all antipsychotics, but it is seldom used to treat schizophrenia. Instead, pimozide is most often used to treat Tourette s syndrome. There is actually no reason why pimozide can t be used to treat psychosis and no reason why other antipsychotics are not effective in Tourette s syndrome. Pimozide was simply used first in controlled clinical trials to treat Tourette s syndrome, and the physicians who routinely treat that illness became accustomed to using it. Pimozide is only available in an oral form. The lack of an injectable form to treat agitated patients as well as the lack of availability of data from controlled trials in schizophrenia patients likely explains why it has not been used very often in the treatment of schizophrenia. 

Antipsychotics. It was recognized some years ago that high potency typical anti-psychotics, that is, haloperidol (Haldol) and pimozide (Orap), were effective in treating OCD patients who had a comorbid tic disorder. The efficacy of these agents, however, is primarily in redncing the tics rather than the core symptoms of OCD. 

In terms of pharmacological action, pimozide is similar to haloperidol. It is used in hospitals as well as in outpatient settings for supportive therapy of patients suffering from schizophrenia, paranoid conditions, and mental and neurotic disorders with paranoid characteristics. It is unfit for use in severe psychoses because it does not possess psychomotor-sedative action. It is used for treating patients who suffer from Turretts s syndrome. Pimozide has a number of side effects, many of which are similar to those of phe-nothiazine and a number of others. A synonym of this drug is orap. 

Ciark ML, Huber W, Serafetinides EA, et ai. Pimozide (Orap). Atoierance study, din Thai J 1971 2(suppi) 25-32. 

Subject N Applica- Monkeys 3 i.v. Humans 12 Oral Humans 6 OraP Humans 13 Oral Humans 13 Oral ... 

ORAP (Gate) (pimozide) tablets August 1999 labeling... 

A recent limited but controlled study indicated that pimozide (Orap) was more effective than carbamazepine. However, the potential for severe extrapyramidal adverse effects with pimozide is considerable, and it is not a drug of choice. 

Moban) olanzapine (Zyprexa) perphenazine (Trilafon) pimozide (Orap) quetiapine (Seroquel) risperidone (Risperdal) thioridazine (Mellaril) thiothixene (Navane) trifluoperazine (Stelazine) trifuluopromazine (Vesprin) ziprasidone (Geodon). 

ORAP Pimozide 1, 2 mg Tablet Tourette s disorder Blockade dopaminergic receptors in the CNS Calcium stearate, MCC, lactose anhydrous, corn starch Gate... 

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