Oral drug delivery solid dosage forms

Another example of an excipient-excipient interaction that can be used to our advantage is the one between xanthan gum and locust bean gum (carob gum or cer-atonia) in the presence of water. This interaction forms the basis of the identification test for Xanthan Gum NF. The interaction creates a much more viscous gel system than can be created using either component alone. This has been used in the formulation of controlled release oral solid dosage forms in the TimeRx drug delivery system (11). 

Cannon, J. (2005) Oral solid dosage forms of lipid-based drug delivery systemSharm. Rey8 108-113. 

Melt Processes for Oral Solid Dosage Forms, p. 2251. Physiological Factors Affecting Oral Drug Delivery, p. 2866. 

The most common method of drug delivery is the oral solid dosage form, of which tablets and capsules are predominant. The tablet is more widely accepted and used compared to capsules for a number of reasons, such as cost, tamper resistance, ease of handling and packaging, ease of identification, and manufacturing efficiency. Over the past several years, the issue of tamper resistance has resulted in the conversion of most over-the-counter drugs from capsules to predominantly all tablets. 

Usually, for oral drug delivery, crystalline solids are preferred. This is especially true for solid dosage forms such as tablets or capsules. 

In the last 15 to 20 years, there has been a huge resource in both academia and industry devoted to the development of drug delivery systems that target drugs more effectively to their therapeutic site. Much of this work has been successful and is reported within this text. In spite of this, oral solid dosage forms such as tablets and hard gelatin capsules, which have been in existence since the nineteenth century, remain the most frequently used dosage forms. This is not simply a reflection of the continued use of established products on the market, tablets and capsules still account for about half of all new medicines licensed (Table 11.1). 

Tan, A., Rao, S., Prestidge, C.A., 2013. Transforminglipid-based oral drug delivery systems into solid dosage forms an overview of solid carriers, physicochemical properties, and biopharmaceutical performance. Pharm. Res. 30, 2993—3017. 

Oral solid dosage forms are most preferred for MPS-based drug delivery. Tablets and capsules are recommended dosage forms for the delivery of poorly soluble drugs using MPS. Wet granulation of drug-loaded MPS improves the flow behavior... 

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