Oral antidiabetic agents, development

Four major classes of oral antidiabetic agents have been developed for the treatment of type 2 diabetes (Figure 16.6) [45]. These include ... 

Oral Antidiabetic Agents The oral hypoglycemics were developed fijom the observation that sulfonamides had hypoglycemic activity. 

Sitagliptin 5 (Januvia, Figure 4.2) is an oral antidiabetic drug of the DPP-4 inhibitor class developed and is marketed by Merck Co. Sitagliptin is used either alone or in combination with other oral antihyperglycemic agents (such as metformin or a thiazolidinedione) for the treatment of type-2 diabetes. 

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