Optofluidic detection

Optofluidic detection techniques based on SERS can be used as a highly sensitive biomedical and chemical sensor. Combining a microfluidic device with Raman spectroscopy provides an opportunity to analyze target molecules in real time without labeling at the single molecular level. There are several methods for combining... 

Rapid Chemical Vapor Detection Using Optofluidic Ring Resonators... 

Erickson, D. Mandal, S. Yang, A. Cordovez, B., Nanobiosensors Optofluidic, electrical and mechanical approaches to biomolecular detection at the nanoscale, Microfluid. Nanofluid. 2008, 4, 33 52... 

Yin D, Lunt EJ, Rudenko MI, Deamer DW, Hawkins AR, Schmidt H (2007) Planar optofluidic chip for single particle detection, manipulation, and analysis. Lab Chip 7 1171... 

Zhu H, White IM, Suter JD et al (2007) Analysis of biomolecule detection with optofluidic ring resonator sensors. Opt Express 15 9139-9146... 

Figure 1. Current Nanoscale Optofluidic Sensor Arrays, (a) 3D rendering of the NOSA device, (b) 3D rendering after association of the corresponding antibody to the antigen immobilized resonator, (c) Experimental data illustrating the successful detection of 45 pg/ml of anti-streptavidin antibody. The blue trace shows the initial baseline spectrum corresponding to Fig. la where the first resonator is immobilized with streptavidin. The red trace shows the test spectra after the association of anti-streptavidin. (d) Finite difference time domain (FDTD) simulation of the steady state electric field distribution within the 1-D photonic crystal resonator at the resonant wavelength, (e) SEM image demonstrating the two-dimensional multiplexing capability of the NOSA architecture.

S. Mandal, J. Goddard, and D. Erickson, A multiplexed optofluidic biomolecular sensor for low mass detection. Lab on a Chip Accepted (accessible on-line) (2009). 

Abstract Optical detection continues to dominate detection methods in microfluidics due to its noninvasive nature, easy coupling, rapid response, and high sensitivity. In this review, we summarize two aspects of recent developments in optical detection methods on microfluidic chips. The first aspect is free-space (off-chip) detection on the microchip, in which the conventional absorption, fluorescence, chemiluminescence, surface plasmon resonance, and surface enhanced Raman spectroscopies are involved. The second aspect is the optofluidic (inside-chip) detection. Various miniaturized optical components integrated on the microfluidic chip, such as waveguide, microlens, laser, and detectors are outlined. 

Song W, Yang J (2012) Optofluidic differential spectroscopy for absorbance detection of sub-nanolitre liquid samples. Lab Chip 12 1251-1264... 

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