Optimal absorption criteria

In the drug discovery process, the selection of a suitable candidate drug is the milestone for continuing into a costly development and clinical phase. Some optimal absorption criteria from a biopharmaceutical point of view are shown below ... 

The presentation here provides an overview of tlie uses of a perfused skin model such as the IPPSF in percutaneous absorption and dermatotoxieokinetie studies. One of its major advantages is that both absorption and toxicity may be assessed in the same preparation. The pharmaeokinetic models developed arc experimentally verifiable. The major limitations are centered on the cost of the preparation and the technical expertise required to successfully conduct the studies. The overall cost is significantly greater than in vitro diffusion cell studies or in vivo rodent experiments, comparable to human skin equivalent and larger mammal (dog, pig, primate) in vivo work and much less expensive than human trials. However, cost alone is not a sufficient criterion. These studies are humane more information may be gathered than is obtainable with either in vitro or in vivo work. Optimal benefit may be achieved if these studies serve as a bridge between in vitro human/animal and in... 

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