Peptides opoid

Examples of the use of analytical-scale column systems for the small-scale (i.e., 1 fig to 1 mg) preparative separation of peptides include the extraordinarily potent opoid peptide, dynorphin (I4S) insulin A-, B-, and C-chain peptides (24, 72) j8-chain peptides of the pituitary glycoprotein hormones (8) endorphins (28,60, 126, 137), adrenocorticotropic peptides in plasma, pituitary, and other endocrine glands or secreted from tumor cells iVt vitro (84, I2S, 127, 138, 142. I Si) hypothalamic releasing factors... 

Houghten RA, Dooley CT. The use of synthetic peptide combinatorial libraries for the determination of peptide ligands in radio-receptor assays opoid peptides. Bioorg. Med. Chem. Lett. 49. 1993 3 405-412. 

Boyce R, Li G, Nestler HP, Suenaga T, Still WC. Peptidosteroidal receptors for opoid peptides, sequence-selective binding using a synthetic receptor library. J. Am. Chem. Soc. 1994 116 7955-7956. 

Dermenkephalin Tyr-DMet-Phe-His-Leu-Met-Asp-NH2 (DREK) (also referred to as deltorphin or dermorphin gene-associated peptide) is a highly potent agonist at the opoid receptor. Whereas, the D-form is a highly potent opoid agonist, [L-Met ] DREK is virtually inactive. 

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