Open Source Drug Discovery

Open Source Malaria Globa] http //openwetware.org/wiki/ Open Source Drug Discovery - Malaria opensourcemalaria.oig/... 

Open Source Drug Discovery Global www.osdd.net/... 

Stahl MT. Open-source software not quite endsville, Drug Discovery Today 2005 10 219-22. 

DeLano WL. The case for open-source software in drug discovery. Drug Discovery Today 2005 10 211-13. 

Another crucial resource is the financial base upon which to develop the API or therapy. In this field, too, the changing structures of markets, financial markets, and the industrial landscape have opened additional sources for drug discovery and development, such as direct access to capital markets and alliances with larger companies. 

Mazanetz MP, Marmon RJ, Reisser CBT, Morao I (2012) Drug discovery applications for KNIME an open source data mining platform. Curr Top Med Chem 12 1965-1979 Warr WA (2012) Scientific workflow systems Pipeline Pilot and KNIME. J Compu Aided Mol Des 26 801-804... 

The use of plants for medicinal purposes is an ancient practice. Nature, with its wealth of traditional knowledge has been the source of inspiration for numerous drugs currently used for the improvement of life as well as treatment for a cure. Considering the beneficial role of many plants and fruits, they were included in the human diets. In many instances, the knowledge of the underlying mechanism of action of a particular natural product is incomplete. Continuous investigation can lead to new mechanisms and new structures, which may open up entirely new windows and perspectives. For instance, before the discovery of apicidin and bispyri-dinium diene, it was believed that unless there is a classical chelator for zinc ion, it cannot be a HDAC inhibitor. SAHA has been approved by FDA, which is inspired from the natural product trichostatin. The natural product, romidepsin has also been approved by FDA and many are on clinical trials. Currently, isozyme-selective inhibition for HDAC is at its nascent stage. The invention of some novel molecules or invention of some novel natural product structures with synthetic modifications will solve the problem. 

Plants remained essentially the sole source of natural product drugs until well into the 20th century. Then in 1928 the discovery of penicillin hy the Scottish bacteriologist Sir Alexander Fleming (1881-1955) opened an entirely new area of research in the held of... 

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