Oncology of Sialoglycoproteins

In accordance with the above structural studies, the specific activity of GlcNAcTV, which synthesizes the (3-1,6 branch, has been shown to be elevated two- to three-fold in the transformed cells (Yamashita et al., 1985 Pierce et al., 1987 Yousefi et al, 1991). In contrast, no change in the specific activities of other glycosyltransferases involved in the synthesis of the A-linked sugar chains was observed in transformed cells (Yamashita et al, 1985). These findings confirm that the increase in the p-1,6-branched chains results from the increased specific activity of GlcNAcTV in transformed cells, although the molecular 

Tumorigenicity and Metastatic Potentials of B16 Mouse Melanoma FIO and Its WGA-Resistant L18 Cells  

Investigations of the allotransplantable ascites subline of TA3 mammary adenocarcinoma provided the first clear evidence of the association of one specific mucin-type glycoprotein with malignancy. A heavily 0-glycosylated pro- 

The metastatic process is very complex and involves numerous steps including detachment of cells from the primary tumor, motility, extravasation. 

Acknowledgments. The investigations of one of us (V.P.B.) in this field have been supported by grants from the USPHS, most recently by grant CA38797 awarded by the National Cancer Institute. We thank Ms. Esha Bhavanandan and Ms. Filomena Cramer for their secretarial assistance. 

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