Oncogene addiction

Sharma SV, Fischbach MA, Haber DA et al. Oncogenic shock explaining oncogene addiction through differential signal attenuation. Clin Cancer Res 2006 12 4392s 395s. 

Workman, P. et al. 2007. Drugging the cancer chaperone HSP90 combinatorial therapeutic exploitation of oncogene addiction and tumor stress. Ann. NY Acad. Sci. 1113, 202-216. 

Observation of a mutation in a particular kinase does not guarantee response to an inhibitor of the kinase itself or its pathway.64 For example, K-RAS mutations do not give sensitivity to inhibitors of downstream kinases such as RAF or MEK. Emerging clinical data is helping to identify tumours with oncogene addiction .53 Here, the functioning of one gene product or related... 

Weinstein IB. Addiction to oncogenes the Achilles heal of cancer. Science 2002 297 63-64. 

Sharma SV, Gajowniczek P, Way IP et al. A common signaling cascade may underlie addiction to the Src, BCR-ABL, and EGF receptor oncogenes. Cancer Cell2006 10 425 35. 

S.B. Baylin, J.E. Ohm, Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction , Nat. Rev. Cancer 2006, 6, 107-116. 

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