On-column inlet

Figure 6.9. On-column inlet design (Hewlett-Packard Co.-Biomedical chromatographs).

The ease of adapting the port to an on-column inlet having an additional heat supply. 

Microbial growth can quickly occur in buffered mobile phases that contain little or no organic modifier. This growth will accumulate on column inlets and can damage chromatographic performance. 

Minimal system requirements are a GC equipped with electronic pneumatic control (EPC), off-the-shelf capillary columns, split/splitless or on-column inlets, standard detectors optimized for capillary columns, and a fast acquisition data system. At any time, users can switch from fast GC back to the original method without major difficulties, or optimize new methods to meet new analytical demands. 

F. David, L. Vanderroost and P. Sandra, Analysis of Polymer Additives Using the HP5890 Series 11, Cool on Column Inlet with Electronic Pressure Control, Hewlett Packard Application Note No. 228-149,1991. 

The cool on-column inlet may be used for all types of analyses, but it excels for analytes that are high-boiling, thermally labile, or otherwise reactive in the inlet. Cool on-column is often used as a control when optimizing other techniques, as it does not suffer from discrimination. Analytical sensitivity is usually very... 

FIGURE 9.11 Schematic of cool on-column inlet. The analytical column or retention gap extends through to the top of the inlet and sample is deposited directly into the column. A duckbill valve or a thin septum may be used with either manual injection... 

On-column inlet the sample is here introduced in its entirety without heat. 

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