Omega-6 fatty acid supplementation

Geusens, P., Wouters, C., Nijs, J., Jiang, Y.B., Dequeker, J. (1994). Long-term effect of omega-3-fatty-acid supplementation Zn active rheumatoid-arthritis — a 12-month, double-blind, controlled study. Arthritis and Rheumatism, 37, 824-829. 

Yuen A. W. C., Sander J. W., Fluegel D., Patsalos P. N., Bell G. S., Johnson T., and Koepp M. J. (2005). Omega-3 fatty acid supplementation in patients with chronic epilepsy A randomized trial. Epilepsy Behavior 7 253-258. 

Park, Y., and Harris, W. S. 2003. Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance. /. Lipid Res., 44,455-463. 

The long-term influence of omega-3 fatty acid supplements is not known, and, for this reason, the American Heart Association has not recommended that supplements be taken (Krauss et al., 1996). There is a very real concern that dietary PUPAs of all types may enhance the accumulation of lipid oxidation products in lipoprotein particles, thus allowing the attack of lipid oxidation products on the pn>tein component of the LDL, the enhanced uptake of the damaged LDL by macrophages in the artery wall, and increased atherosclerosis (Allard ei ai, 1997 Felton ct si., 1994), (Monounsaturaled fatty acids are thought not to be involved in the oxidation scenario lead big to atherosclerosis.)... 

Bennett WM, Carpenter CB, Shapiro ME, Strom TB, Hefty D, Tillman M, Abrams J, Ryan D, Kelley VR. Delayed omega-3 fatty acid supplements in renal transplantation. A double-blind, placebo-controlled study.Transplantation 1995 59 352-356. 

C. Klemens, D. Berman, E. Mozuikewich (2009) A meta-analysis of perinatal omega-3 fatty acid supplementation on inflammatory markers, allergy, atopy, and asthma in infancy and childhood. Am J. Obstet. Gynecol, 201, S228. 

Mellor, J.E., Laughame, J.D., and Peet, M. 1996. Omega-3 fatty acid supplementation in schizophrenia patients. Hum. Psychopharmacol. 

Omega-3 fatty acids supplementation may lower blood pressure by their antihypertensive and hypotriglyceridemic effects, and add to the effects of drugs that may also affect blood pressure, such as beta-blockers or diuretics. ... 

Omega-3 fatty acid supplementation has been utilized for muscle inflammation and soreness, and its use is based on the anti-inflammatory response that these... 

Romano, C, Cucchiara, S., Barabino, A., Annese, V., and Sferlazzas, C, Usefulness of omega-3 fatty acid supplementation in addition to mesalazine in maintaining remission in pediatric Crohn s disease a double-blind, randomized, placebo-con-trolled study. World J. Gastroenterol., 11, 7118-7121, 2005. 

Thomas, T.R., Smith, B.K., Donahue, O.M., Altena, T.S., James-Kracke, M., and Sun, G. Y., Effects of omega-3 fatty acid supplementation and exercise on low-density lipoprotein and high-density lipoprotein subtractions. Metabolism, 53, 749-754, 2004. 

Raastad, T, Hostmark, A.T., and Stromme, S.B., Omega-3 fatty acids supplementation does not improve maximal aerobic power, anaerobic threshold and running performance in well trained soccer players, Scand. J. Med. Sci. Sports, 1, 25-31, 1997. 

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