Omega-6 fatty acid deficiency

Neuringer, M., Connor, W. E., Lin, D. S., Barstad, L., and Luck, S. (1986). Biochemical and functional effects of prenatal and postnatal omega-3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc. Natl. Acad. Sci. USA 83, 4021-4025. 

Neuringer M, Connor WE, V an Petten C, Bars tad L. Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. J Clin Invest 1984 73 272-276. 

An observational study with the blind observers found that rhesus monkeys whose diet was deficient in omega-3 fatty acid initiated more bouts of stereotyped behavior in their cages than monkeys who had received a control diet abundant in omega-3 fatty acids. These stereotyped behaviors associated with the omega-3 fatty acid deficiency were typical of rhesus monkeys raised as partial social isolates or those whose surroundings had been disrupted. The control monkeys had much less stereotypical behavior. It was noted also that stereotypic behavior decreased after meals in males, but not in females. Again, these seemed to be related to central effects on the behavior of n-3-deficient monkeys (Connor et al., 1969). 

Armitage J, Weisinger H. Vingrys A, et al. Perinatal omega-3 fatty acid deficiency alters ERG in adult rats irrespective of tissue fatty acid content. [ARVO Abstract]. Invest Ophthalmol Vis Sci 2000 41 S245. 

Reisbick S, Neuringer M, Connor WE, Iliff-Sizemore S. Increased intake of water and NaCl solutions in omega-3 fatty acid deficient monkeys. Physiol Behav 1991 49 1139-1146. 

Postnatal Omega 3 Fatty Acid Deficiency on Retina and Brain in Rhesus Monkeys, Proc. Natl. Acad. Sci. USA 83,4021-4025. 

Neuringer, M., Connor. W.E.. Van Petten. C.. and Barstad, L. (1984) Dietary Omega-3 Fatty Acid Deficiency and Visual Loss in Infant Rhesus Monkeys, J. Clin. Investig. 73.272-276. 

Reisbick, S., and Neuringer, M. (1997) Omega-3 Fatty Acid Deficiency and Behavior A Critical Review and Future Directions for Research, in Handbook of Essential Fatty Acid Biology Biochemistry, Physiology and Behavioral Neurobiology (Yehuda, S., and Mostofsky, D.I., eds.) pp. 397-426, Humana Press, Totowa, NJ. 

Weisinger, HS, Armitage, JA, Sinclair, AJ, Vingrys, AJ, Bums, PL and Weisinger, RS (2001) Perinatal omega-3 fatty acid deficiency affects blood pressure later in life. Nature Med., 7, 258-259. 

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