Fucosylated oligosaccharide

Newburg, D. S., Ruiz-Palacios, G. M., Altaye, M., Chaturvedi, P., Guerrero, M. L., Meinzen-Derr, J. K., and Morrow, A. L. (2004). Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breast-fed infants. Glycobiology 14, 253-263. 

Ajisaka K, Eujimoto H, Miyasato M An alpha-L-fucosidase from Penicillium multicolor as a candidate enzyme for the synthesis of a(1 3)-linked fucosyl oligosaccharides by transglycosylation. Carbohydr. Res. 1998 309 125-129. 

L-Fucose occurs either at terminal or preterminal positions of many cell surface oligosaccharide ligands. These fucosylated oligosaccharides mediate cell-cell recognition and adhesion-signaling pathways. Some of these processes... 

J. B. Lowe, Ligands for E-selectin-biosynthesis of sialylated, fucosylated oligosaccharides, in M. Fukuda and O. Hindsgaul (Eds.), Molecular Glycobiology, Oxford University Press, Oxford, 1994, pp. 177-178. 

D. S. Newburg, L. K. Pickering, R. H. McCluer, and T. G. Cleary, Fucosylated oligosaccharides of human milk protect suckling mice from heat-stabile enterotoxin of Escherichia coli, J. Infect. Dis., 162 (1990) 1075-1080. 

Fucosylated oligosaccharides are important components of glycoproteins and glyco-lipids which are usefiil for cancer diagnosis and immunotyping. Therefore, efficient production methods for L-fucose and its analogs would be usefiil. 

Interest in fucosylation of glycoconjugates is connected with higher fucosylation rates in aberrant tissue. Thus it was attempted to use enzymatic fucosylation processes to obtain fucosylated oligosaccharides. The isolation of a-L-fucosidase from porcine liver is performed, after... 

By this process the activated fucose species is readily at hand for several fucosyltransferase-catalyzed reactions towards fucosylated oligosaccharides. 

B.W. Grinnell, R.B. Hermann and S.B. Yan, Human protein C inhibits selectin-mediated cell adhesion Role of unique fucosylated oligosaccharide. Glycobiology, 1994, 4, 221 225. 

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