Oligomeric intermediates

The issue of nucleation and growth is complicated by the formation of oligomeric and polymeric species in solution and their precipitation onto the electrode surface, which may be the primary mechanism for nuclei formation.62 The expansion of nuclei and film growth arise both from the precipitation of oligomeric intermediates formed in solution and... 

Prakash K, Prajapati S, Ahmad A et al (2002) Unique oligomeric intermediates of bovine liver catalase. Protein Sci 11 46-57... 

Lee HJ, Khoshaghideh F, Patel S, Lee SJ (2004) Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradadon pathway. J Neurosci 24 1888—1896. 

It was found that the choice of substituents on the binaphthyl groups strongly affected the diastereo-meric formation of oligomeric intermediates, the screw sense of which was maintained in the further helix-sense-selective propagation steps.238... 

Native state (N) is formed from the unfolded state through intermediate(s) (I). The intermediate(s) acts as a template and propagates to form ordered oligomeric intermediates or protofibrils (PF), which builds up to form stable, insoluble fibrils (F) as shown in Fig. 2. The reaction mechanism involved in this sequence is similar to initiation, propagation, and termination steps in a polymerization reaction. Amorphous aggregates, formed are in equilibrium with the intermediates. In other words, this process is reversible. However, amyloid fibrils are the byproducts of irreversible protein aggregation. 

Carrotta, R. Bauer, R. Waninge, R. Rischel, C. Conformational characterization of oligomeric intermediates and aggregates in P-lactoglobulin heat aggregation. Protein Sci. 2001,10 (7), 1312-1318. 

Standardized DIN tests using Daphnia magna and luminescent bacteria were apphed to assess the ecotoxicity of synthetic aliphatic-aromatic copolyester [18]. No significant toxicological effect was observed neither for the monomeric intermediates nor for the oligomeric intermediates. 

The different degradation behaviour of the synthetic aromatic model - oligomers and the aromatic oligomeric intermediates which are really formed during the polyester... 

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