Oligodendroglia cells

In tissue culture, the glial cells derived from posterior lobes of dog and rat had the same morphological characteristics as protoplasmic astrocytes derived from various parts of the brain (Hild 1954). Oligodendroglia cells were sometimes observed in cultures of posterior lobe macrophages, which according to the investigations of Costero (1930) are probably identical with microglial, are a very common observation. 

CNS development are employed for the same purpose in the PNS. PNS microglia-like cells, like microglia in the CNS, are bone-marrow-derived and have a similar repertoire of responses to activation [2], Both oligodendroglia and Schwann cells speed axonal action potential propagation by assembling and maintaining myelin. Capillary endothelial cells linked by tight junctions restrict entry of polar molecules into the PNS, as into the CNS [3],... 

Schwann cells are responsible for PNS trophic functions that, in CNS, are carried out by both oligodendroglia and astroglia. Schwann cell diseases usually present as disorders of myelination. Axonal degeneration and diminution in axonal diameter may also occur in primary disorders of Schwann cells, as a consequence of loss of Schwann cell trophic support for axons. (See also Chs 4 and 38.)... 

To assess the protective abilities of these chelators, a spontaneously transformed cell line of oligodendroglia origin (OLN 93) was chosen as a model for neural cells. These cells were previously used to demonstrate a remarkable sensitivity to genotoxic stress, culminating in cell death when both divalent iron and H2O2 were added to cells °. ... 

The biochemical parameters of myelination appear to be controlled in a coordinated manner. That is, the parameters we measured responded in the same direction and degree to a certain condition of growth. For example, the cyclic nucleotide phospho-hydrolase and incorporation of into lipids both were less active in cultures from the newborn mouse than from the 15 day fetus. In addition the developmental pattern of all of the activities measured occurred in parallel and were all highest at about the same growth period. This coordinated control suggests that they are derived from a central source, such as a single cell type (for example, oligodendroglia) of brain. 

Oligodendroglia One of the three types of glia cells responsible for creating the myelin sheath surrounding neurons in the CNS. 

As reviewed here, cannabinoids may lead to opposite effects on the cell sur-vival/death decision. For example, in the case of neural cells, cannabinoids may kill tumour cells and protect their non-transformed counterparts from death (Guzman 2003) (Fig. 1). It is conceivable that different experimental factors may account for this yin-yang action, for example (1) cannabinoid neuroprotection is usually more evident in whole-animal than in cultured-neuron models, which may result from their aforementioned impact on various brain cell types (neurons, astroglia, oligodendroglia, microglia, vascular endothelium) (2) cannabinoids may exert... 

These tumors have prominent cells that resemble oligodendroglia and NF-positive neurons (or synaptophysin-positive neurons, or both) that often appear to float within Alcian blue-positive acid mucopolysaccharide. These are called floating neurons (see Fig. 20.35B). Other large neurons lack their normal spacing (see Fig. 20.35C). GFAP-positive astrocytes are variably present within the tumor and often surround it. This tumor s low MIBl LI, mature histotopographic appearance, and... 

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