Oligemia

In discussing the effect of mustard on the intestinal tract, Cullumbine pointed out that severely poisoned men suffered loss of water and electrolytes because of vomiting, diarrhea, and vesication. Oligemia and irreversible circulatory failure follow, much as in thermal burns. He showed the importance of the loss of water and electrolytes by experiments in which the mortality rate of poisoned rats and rabbits was greatly reduced by the administration of physiologic saline solution either by mouth or by injection. 

Fig. 4.12. Mismatch concept of diffusion lesion (smaller) and perfusion deficit (larger) in human territorial brain infarction. Acute MCA territory ischemia/oligemia with a smaller, centrally located diffusion disturbance showing the relationship between infarct core, ischemic penumbra and changes in DWI and PI. DWI, diffusion-weighted imaging PI, perfusion imaging ADC, apparent diffusion coefficient ATP, high energy phosphates MCA, middle cerebral artery...

Swap, C., et al. Degree of oligemia by perfusion-weighted CT and risk of hemorrhage after lA thrombolysis, in Stroke -Proceedings of the 27th International Conference on Stroke and Cerebral Circulation. 2002. San Antonio, TX. 

If vasodilation is unsuccessful in maintaining CBF, PWl may demonstrate a reduction in CBF, in addition to the changes in CBV and MTT. With sufficiently mild CBF reduction, a condition sometimes called benign oligemia, the survival of the affected brain tissue is not threatened, and the patient may or may not even experience an associated neurologic deficit. Flowever, with more severe reductions in blood flow, ischemic damage accrues, and this damage becomes irreversible after a period of time whose duration is inversely related to the... 

Salford LG, Plum F, Siesjo BK (1973) Graded hypoxia-oligemia in rat brain. I. Biochemical alterations and their imphcations. Arch Neurol 29 227-233... 

Mean transit time and time to peak are the most commonly used parameters for evaluating abnormal perfusion. Some studies have employed a quantitative threshold-based approach to exclude regions of benign oligemia... 

Fig. 4.1 Relative cerebral blood flow thresholds resulting in a range of functional perturbations in the brain. The range of cerebral blood flow on the abscissa range from normal, oligemia, state where total blood volume is reduced, and ischemia...

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