Olfaction and memory

The entorhinal cortex receives a substantial input from the MOB (Broadwell, 1975 De Olmos et al. 1978 Kosel et al. 1981 Shipley and Adamek, 1984). In turn, the medial and lateral entorhinal cortex projects to the dentate gyrus and CA fields of the hippocampus (Hjorth-Simonsen, 1972 Steward, 1976). Recent studies show that MOB projections to entorhinal cortex make direct contact with stellate cells located in layer II that in turn project via the perforant path to the hippocampus (Schwerdtfeger et al. 

In addition, piriform cortex has direct connections to the entorhinal cortex. Because the hippocampus is important in memory function, these olfactory-entorhinal-hippocampal circuits may be important for establishment or recall olfactory memories formed or associated with other events. 

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