Olanzapine susceptibility factors

There are multiple susceptibility factors for olanzapine-induced prolongation of the QT interval female sex, old age, concomitant medications, and underlying cardiac conduction disorder. 

Cardiovascular Clozapine, which is close related to olanzapine, has been implicated as an independent susceptibility factor for pulmonary embolism [SEDA-28, 65]. A possible association between olanzapine and pulmonary thromboembolism has also been described [SEDA-32,102]. New cases have been reported [97", 98" ]. 

Susceptibility factors A study of tumour necrosis factor-alpha (TNF-a) in 99 patients with bipolar depression found that treatment with olanzapine, quetiapine, risperidone, paliperidone or clozapine was associated with significantly greater TNF-a and a higher likelihood of metabolic syndrome [74FI TNF-a was greater in those with metabolic syndrome and there was a significant effect on the indirect relationship between antipsychotic treatment and elevated waist circumference. 

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