Olanzapine sexual function

Endocrine Aripiprazole is said to stabilize the dopaminergic system and thus ameliorate schizophrenic symptoms without increasing serum prolactin [SEDA-31, 76]. Prolactin concentrations and sexual function in schizophrenic patients have been evaluated in an open, 26-week, multicenter study, in which 555 patients were randomized to aripiprazole ( = 284) or standard care (olanzapine, quetiapme, or risperidone n = 271) [69 ]. At 8 weeks, those who took aripiprazole reported significantly greater improvement in sexual function. Baseline mean serum prolactin concentrations were similar in the two groups (434 and 423 mg/1 respectively) however, at week 26, the mean fall in serum prolactin was 342 mg/1 with aripiprazole compared with 133 mg/1 with the other treatments. 

Sexual function A study of 100 men with psychotic disorders found that the rate of sexual dysfunction was highest for risperidone, followed by trifluoperazine and olanzapine, measured on three different scales [73 ]. Rates of sexual function varied according to the scale used decreased libido was the most prevalent except for orgasmic disorders for risperidone on the ASEX scale. 

---