Of soyasaponins

Fig. (1). Effects of Extract of Abri Herba in Mice Treated with CC14 Effects of Soyasaponin I (Soya I), total OG-I (OG-I) and total OG-II (OG-II) on CC14 induced liver injury by oral administration. These doses were each 500mg/kg. Each column represents mean of 10 mice. p<0.05, p<0.01. AST (aspartate aminotransferase), ALT (alanine aminotransferase)...

Fig. (7). Hepatoprotective Actions of Soyasaponins I - IV toward in vitro Immunological Liver Injury on Primary cultured Rat Hepatocytes Control (Cont.) is the value of hepatocytes which were not administered the antiserum. Reference (Ref.) value were administered the antiserum and not treated with Soyasaponins I (A), II (B), III (C), IV (D). Significantly different from Ref., effective p <0.01.

Table 6. Anti-complementary Activity of Soyasaponin I, Kaikasaponin...

The effect of soyasaponins on tumor cells may be mediated by mechanisms other than membrane permeability, because of their weak hemolytic activity. Saponins actively interact with cell membrane components, resulting in changes in intracellular morphology and cell membrane permeability. However, the differences between types of saponins and their effects on cell membrane are evident. 

Fig. (13). Effects of soyasaponins on parametrial adipose tissue weight in GTG-treated mice. Results are expressed as mean S.E. of 30 mice.

G (25) and soyasaponins I (26) exhibited remarkable inhibitory effects on EBV-EA activation but A and G have strong cytotoxicities on Raji cells. In these experiments the remarkable effect of soyasaponin I (more than 55-47% inhibition of activation at 5 x 102 mol ratio/TPA) was stronger than that of glycyrrhetic acid (23a) which is known as a strong antitumor promoter and it preserved the high viability of Raji cells [29, 30]. 

The activities of soyasaponin I (26) and II (26b) were studied in vitro against HSV-1 [153]. Soyasaponin II was more potent than soyasaponin I as shown by the reduction of HSV-1 production. Soyasaponin II also inhibited the replication of HCMV, HIV-1 and influenza virus. The action was not due to inhibition of virus penetration and protein synthesis, but might involve a virucidal effect. Additive antiviral effects were observed when soyasaponin II (200 pM and lOOOpM) was evaluated in combination with acyclovir (1,5, and 25 pM) for anti-HSV-1 activity... 

Kim, S. M.A. Berhow J. Kim H. Chi S. Lee I. Chung. Evaluation of soyasaponin, isoflavone, protein, lipid, and free sugar accumulation in developing soybean seeds. /. Agric. Food Chem. 

Hayashi, H., Huang, P, and Inoue, K. Up-regulation of soyasaponin biosynthesis by methyl jasmonate in cultured cells of Glycyrhiza glabra. Plant Cell Physiol. 44,404-411, 2003. 

As shown in Fig. (12), both afromosin (21) and soyasaponin I (105), when applied continuously before each TPA treatment, delayed the formation of papillomas and reduced the number of papillomas per mouse as compared with the control experiment with only TPA. Furthermore, the combined application of soyasaponin I with afromosin significantly enhanced the inhibitory effects both on the rate of papilloma-bearing mice... 

Occurrence of Soyasaponin I and Mono- and Bidesmosides Studied by Thin Layer Chromatography (TLC). Preparative TLC was used to fractionate the crude saponins from... 

Other Plants As stated in Puerariae Radix, we have examined the hepatoprotective activity of soyasaponins I-IV obtained from wild soya, namely. Glycine soya [27]. 

Fig, 6, Hepaioproiective Activity of Soyasaponins ] IV from Giycine soya... 

Abstract—This review is about the studies on biological activities of soyasaponins(ss).These studies show that ss have extensive biological activities and pharmocological values.Thus, ss may become new drug resources for treating angiocardiopathy and inhibiting cancer. 

Hayashi, H., T. Sakai, H. Fukui, and M. Tabata Formation of Soyasaponins in Licorice Cell Suspension Cultures. Phytochem., 29, 3127 (1990). 

Shibuya M, Nishimura K, Yasuyama N, Ebizuka Y (2010) Identification and characterization of glycosyltransfeiases involved in the biosynthesis of soyasaponin I in Glycine max. FEES Lett 584 2258-2264... 

Gurfinkel, D.M., Reynolds, W.F., and Rao, A.V. 2005. The isolation of soyasaponins by fractional precipitation, solid phase extraction, and low pressure liquid chromatography. International Journal of Food Sciences and Nutrition, 56, (7), 501-519. 

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