Of Irritative Motions

The cure of vertigo will frequently depend on our previ-oufly inveftigatmg the caufe of it, which from what has been delivered above may originate from the diforder of any part of the great tribes of irritative motions, and of the affociate motions catenated with them. 

Thefe promote both the fecrctions and abforptions in-creafe the natural heat, and remove thofe pains, which originate from the defect of irritative motions, termed nervous pains and prevent the convulfions confequent to them. When given internally they induce coftivenefs, and deep coloured urine and by a greater dofe intoxication, and its confequences. 

Thefe decreafe the natural heat and remove pains occafioned by excefs of irritative motions. 

Methylscopolamine is a QTA obtained by N-methylation of scopolamine (Fig. 1). It exhibits non-selective antimuscarinic activity and is used as adjunctive therapy for the treatment of peptic ulcer, to treat nausea and vomiting due to motion sickness and for the management of irritable bowel syndrome [75], The tritiated form of methylscopolamine is often used in in vitro MR binding assays to investigate receptor affinity and competition by other agents [76],... 

I. Irritative motions. That exertion or change of the fenfo-rium, whicTr is caufed by the appulfes of external bodies, either fimply fubfides, or is fucceeded by fenfation, or it produces... 

There is another tribe of defires, which are commonly termed appetites, and are the immediate confequences of the abfence of fome irritative motions. Thofe, which arife from defeCl of internal irritations, have proper names conferred upon them, as hunger, thirft, luft, and the defire of air, when our refpiration is impaired by noxious vapours and of warmth, when we are... 

If a ftimulus, which at firft excited the afFe fed organ into fo great exertion as to produce fenfation, be continued for a certain time, it will ceafe to produce fenfation both then and when repeated, though the irritative motions in confequence of it may continue or be re-excited. 

I. A quantity of ftimulus greater than natural, producing an increafed exertion of fenforial power, whether that exertion be in the mode of irritation, fenfation, volition, or aflTociation, dimin ilhes the general quantity of it. This fadt is obfervable in the progrefs of intoxication, as the increafed quantity or energy of the irritative motions, owing to the ftimulus of vinous fpirit, introduces much pleafurable fenfation into the fyftem, and much exertion of mufcular or fenfual motions in confequence of this... 

A certain quantity of ftimulus, lefs than that above men tioned, is Aicceeded by paralyfis, firft of the voluntary and fenfi-tive motions, and afterwards of thofe of irritation and of alTocia-tion, which conftitutes death. 

IV. The aflbeiations of fibrous motions are obfervable in the vegetable world, as well as in the animal. The divifions of the leaves of the fenfitive plant have been accuftomed to contrad at the fame time from the abfence of light hence if by any other circumftance, as a flight ftroke or injury, one divifion is irritated into contradion, the neighbouring ones contrad alfo, from... 

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