Of cyclic peptides

Jorgensen, W.L. Tirado-Rives, J. The OPLS potential functions for proteins. Energy minimizations for crystals of cyclic peptides and crambin. J. Am. Chem. Soc. 110 1657-1666, 1988... 

The OPLS Potential Function for Proteins. Energy Minimization for Crystals of Cyclic Peptides and Crambin William L. Jorgensen and Julian Tirado-Rives Journal of the American Chemical Society 110 (1988) 1657... 

Imanishi, Y. Synthese, Conformation, and Reactions of Cyclic Peptides. Vol. 20, pp. 1 — 77. Inagaki, H. Polymer Separation and Characterization by Thin-Layer Chromatography. Vol. 24, pp. 189-237. 

Imanishi, Y. Syntheses, Conformation, and Reactions of Cyclic Peptides. Vol. 20, pp. 1-77. 

Antitumor evaluation of cyclic peptides and macrolides from Lissoclinum 30... 

Kessler, H. Peptide conformations. 19. Conformation and biological activity of cyclic peptides. Angew. Chem. Int. Ed. 

Mazaleyrat, J.-P. Reboud-Ravaux, M. Wakselman, M. Synthesis and enzymic hydrolysis of cyclic peptides containing an anthranilic acid residue. Int. J. Peptide Protein Res. 1987, 30, 622-633. 

Figure 6.10. Nomenclature of product ions of cyclic peptides.

Incorporation of the Third Protected Amino Acid to Circumvent the Diketopiperazine Side Reaction That Occurs during Syntheses of Cyclic Peptides (R1 = C02Allyl) (Note 15)... 

The crude extract from Guam specimens inhibits fishes and a mixture of cyclic peptides containing laxaphycin A deters feeding by the fish Scarus schiegeii, the sea urchin Diadema savignyi, and the crab Leptodius sp. (Pennings et al. 1997)... 

Garrigues et al. [49] characterized two different but partially overlapping P-gp pharmacophores. Initially, they determined affinities and mutual relationships from the changes in P-gp ATPase activity induced by a series of cyclic peptides, peptide-like compounds used alone or in combination. Because verapamil binding to P-gp... 

FIGURE 5.23 Synthesis of cyclic peptides by head-to-tail cyclization of resin-bound peptides using Boc/Bzl chemistry59 and Fmoc/tBu chemistry.60 The carboxy-terminal protectors are orthogonal to the other protectors. The nature of the linker determines the nature of the product. Both chemistries are compatible with the two types of linkers. All = allyl. 

P Rovero, L Quartara, G Fabbri. Synthesis of cyclic peptides on solid support. Tetrahedron Lett 23, 2639, 1991. 

P. M. Hardy B. Ridge, Recent Advances in the Chemistry of Cyclic Peptides. In Progress in Organic Chemistry W. Carruthers,... 

Amatoxins are a family of cyclic peptides, with oc-amanitin and 3-amanitin (Figure 3.1) accounting for >90% of the total amatoxins. In A. virosa, mushrooms collected in Virginia a-amanitin found to be completely replaced by amaninamide (Figure 3.1). The peptides are not destroyed by cooking and... 

Horton, D.A., Bourne, G.T., and Smythe, M.L. Exploring privileged stmctures the combinatorial synthesis of cyclic peptides./. Comput.-Aided Mol. Des. 2002, 36,415-430. 

The cyclosporins are a group of cyclic peptides produced by fungi such as Cylindrocarpon lucidum and Tolypocladium inflatum. These agents show a rather narrow range of antifungal activity, but high levels of immunosuppressive and anti-inflammatory activities. The main component from the culture extracts is cyclosporin A, but some 25 naturally occurring cyclosporins have been characterized. 

Recent examples of successful peptide-ligand based discoveries of drug-like peptidomimetics include the discovery of SST antagonists, or the discovery of non-peptidic antagonists of the recently deorphanized urotensin II receptor at Sanofi-Aventis. ° As illustrated in Fig. 3, Flohr etal. used 3D models of the NMR solution structure of cyclic peptide derivatives of Urotensin II as a template for virtual 3D pharmacophore searches which resulted into non-peptidic candidates for lead optimization. 

Horton DA, Bourne GT, Smythe ML (2002) Exploring privileged structures the combinatorial synthesis of cyclic peptides. Mol Divers 5(4) 289-304... 

The widespread occurrence of cyclic peptides and depsipeptides in natura makes the research on the development of rapid and efficient approaches for their generation mandatory. The rational design of synthetic cycfic peptide analogs, focused on biological activities that imitate natural structural motifs (turns, hefices, etc.), can help to increase their native properties and to adapted them for human applications, for example, in medicine [12-14]. 

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