Ocular tissue adhesives

Ocular irrigating solutions and disinfectants 242 Viscoelastic materials 242 Intracameral fibrinolytic agents 242 Topical hyperosmotic agents 242 Ocular tissue adhesives 242... 

The cells from the third category, such as epithelial cells isolated from mammal glands, testes, ovaries, pituitary gland, prostate, and from ocular tissue, generally proliferate with more difficulty in a defined medium. Besides maintenance factors, these cells may also need proteins from the ECM to promote their adhesion. Those proteins can be collagen, fibronec-tin, or laminin. Non-peptide factors, such as retinol (50 ng/ml) and corticosteroids (10-100 ng/ml), may also be necessary. 

Ocular Tissue Bonding In Vitro. Two model systems were designed for the evaluation of MAP adhesives in vitro. Bovine eyes obtained the same day from abattoirs were always used. 

Laaksonen T, Santos H, Vihola H, Salonen J, Riikonen J, Heikkila T, Peltonen L, Kumar N, Murzin D, Lehto V, Hirvonen J (2007) Failure of MTT as a toxicity testing agent for mesoporous silicon microparticles. Chem Res Toxicol 20(12) 1913-1918 Low SP (2008) Development of porous silicon as a scaffold for the delivery of cells into ocular tissue. Flinders University, Department of Chemistry Low SP, Williams KA, Canham LT, Voelcker NH (2006) Evaluation of mammahan cell adhesion on surface modified porous silicon. Biomaterials 27 4538-4546 Masters J (2000) Animal cell culture a practical approach. OUP, Oxford... 

Used for ocular bums as soon as 1947 by Sorsby [30], the amniotic membrane is a tissue located at the interface of the placenta and the amniotic fluid. It is constituted of an unstratifled epithelium, a basement lamina, and an avascular mesenchyma. The amniotic membrane facilitates the reepithelialization by reducing the inflammatory and cicatricial reaction [31]. It helps the migration of the epithelial cells and the adhesion of the basement cells [32]. It behaves as an actual replacing basement membrane and facilitates the phenotypic... 

One particularly promising material is AM. The biological properties of AM lends to its attractiveness for application to clinical and surgical practice. AM can reduce inflammation, inhibit vascularization, combat infection, and limit postoperative adhesion. It has been used to treat a variety of diseases such as nonhealing skin ulcers, vaginal atresia, and severe ocular surface disease. Moreover, it can serve as adjunctive tissue... 

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