Vaginal atresia

Lower tract defects Vagiaal aplasia Imperforate hymen Congenital vaginal atresia Uterine disorders... 

One particularly promising material is AM. The biological properties of AM lends to its attractiveness for application to clinical and surgical practice. AM can reduce inflammation, inhibit vascularization, combat infection, and limit postoperative adhesion. It has been used to treat a variety of diseases such as nonhealing skin ulcers, vaginal atresia, and severe ocular surface disease. Moreover, it can serve as adjunctive tissue... 

Intermediate-duration studies with treated females show that exposure to chlordecone may result in persistent vaginal estrus, decreased ovulation, and reproductive failure. Persistent vaginal estrus was observed in female mice at doses as low as 2 mg/kg/day for 3-6 weeks (Huber 1965 Swartz and Mall 1989 Swartz et al. 1988). Increased atresia of follicles (Swartz and Mall 1989), decreased ovulation (Swartz et al. 1988), and small and medium-sized follicles (Swartz and Mall 1989) have been observed after 4 weeks of exposure to 8 mg/kg/day of chlordecone. Similarly, decreased corpora lutea have been observed following administration of 3.9 mg/kg/day for 130 days (Huber 1965). Decreased numbers of litters or complete reproductive failure have been observed after exposure of female rats to 1.62-1.71 mg/kg/day for 4.5 months or female mice to 5.2 mg/kg/day for 160 days (Huber 1965). 

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