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Ocular, 160 methylcellulose

A popular approach to improve ocular drag bioavailability is to incorporate soluble polymers into an aqueous solution to extend the drug residence time in the cul-de-sac. It is reasoned that the solution viscosity would be increased and hence solution drainage would be reduced. The more commonly used viscolyzing agents include PVA and derivatives of cellulose. Cellulosic polymers, such as methylcellulose, hydroxyethylcellulose (HEC), hydroxypropyl-methylcellulose (HPMC) and hydroxypropylcellulose (HPC), are widely used as viscolyzers showing Newtonian properties. They have common properties ... [Pg.308]

Like PVA, the viscosity enhancer hydroxypropyl methyl-cellulose is available in a variety of molecular weights and in formulations with different group substitutions. It has been shown to prolong tear film wetting time and to increase the ability of fluorescein and dexamethasone to penetrate the cornea. Hydroxypropyl methylcellulose 0.5% has been shown to exhibit twice the ocular retention time of 1.4% PVA. [Pg.32]

Stamper RL, DiLoreto D, Schacknow P. Effect of intraocular aspiration of sodium hyaluronate on postoperative intraocular pressure. Ophthalmic Surg 1990 21 486-491 Steele ADM. Viscoelastic materials in keratoplasty. Trans Ophthalmol Soc UK 1983 103 268-269 Steele EA. Hydroxypropyl methylcellulose used as a viscoelastic fluid in ocular surgery, in Rosen ES (ed) Viscoelastic Materials Basic Science and Clinical Applications. New York, Pergamon Press, 1989,S. 161-163... [Pg.144]

Sensory systems Excessive lacrimation is common with fluorouracil and affects 30% of patients [82 ]. Other ocular adverse reactions include blurred vision, ocular irritation and pain, photophobia, conjunctivitis, circu-morbital edema, ectropion, keratitis, and tear duct stenosis. Most patients can be managed symptomatically with methylcellulose or dexamethasone eye drops. Occasionally fluorouracil may need to be withdrawn and the symptoms usually resolve in 1-2 weeks [18 ]. Optic neuropathy is rare [79 ]. [Pg.738]

O.V.Khutoryanskaya,P.W.J.Morrison,S.K.Seilkhanov,M.N.Mussin,E.K.Ozhmukhametova, T.K. Rakhypbekov, and V.V. Khutoryanskiy, Hydrogen-bonded complexes and blends of poly(acrylic acid) and methylcellulose Nanoparticles and mucoadhesive films for ocular delivery of riboflavin, Macromol Biosci, 14,225-234,2014. [Pg.456]

Adler, C.A., Maurice, D.M. and Paterson, M.E., 1971, The effect of viscosity of the vehicle on the penetration of fluorescein into the human eye. Exptl. Eye Res. 11 34 Blaug, S.M. and Canada, A.T., 1965, Relationship of viscosity, contact time and prolongation of action of methylcellulose-containing ophthalmic solutions. Amer. J. Hosp. Pharm., 22 662 Bungaard, H., Buur, A., Chang, S-C. and Lee, V.H.L., 1988, Timolol prodrugs synthesis, stability and lipophilicity of various alkyl, cycloalkyl and aromatic esters of timolol. Int J. Pharm., 46 77 Chrai, S.S. and Robinson, J.R., 1974, Ocular evaluation of methylcellulose vehicle in albino rabbits. [Pg.158]


See other pages where Ocular, 160 methylcellulose is mentioned: [Pg.459]    [Pg.468]    [Pg.743]    [Pg.756]    [Pg.32]    [Pg.222]    [Pg.241]    [Pg.110]    [Pg.159]    [Pg.171]    [Pg.1174]    [Pg.1176]    [Pg.111]    [Pg.153]   
See also in sourсe #XX -- [ Pg.37 , Pg.80 ]




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