Ocular irritation 1004 INDEX

Table 10 gives the ocular irritation index for each product, along with its classification. The differences between the products are marked While LAM and LDAB were irritants at 10% (w/v), lipopeptides Ci2ArgGly and Ci2Arg pp were quite nonirritant, perhaps because their chemical compositions resem-... 

Gillman, M.R., Jackson, E.M., Cerven, D.R. and Moreno, M.T. (1983). Relationship between the primary dermal irritation index and ocular irritation. J. Toxicol. - Cut. Ocular Toxicol. 2 107-117. 

Irritancy Ocular Irritancy Irritancy Index Result Class... 

Various lecithin-based MEs were also characterized by Hasse and Keipert [131]. The formulations were tested in terms of their physicochemical parameters (pH, refractive index, osmolality, viscosity, and surface tension) and physiological compatibility (HET-CAM and Draize test). In addition, in vitro and in vivo evaluations were performed. The tested MEs showed favorable physicochemical parameters and no ocular irritation as well as a prolonged pilocarpine release in vitro and in vivo. 

The LjD ratio is the relationship between the HC50 and the hemoglobin denaturation index (DI). This ratio is used to predict the potential ocular irritation of these surfactants relating to the SDS compound (L/Z>sds 0.44 irritant). According to the results of the LjD ratio first and by the in vivo eye irritation Draize test later (see Table 2), these linear arginine-based surfactants have no irritant effect in the eyes (non-eye irritants, LjD > 100). 

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