Octadecyl butyrate

Successful results have been obtained (Renfrew and Chaney, 1946) with ethyl formate methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec.-butyl and iso-amyl acetat ethyleneglycol diacetate ethyl monochloro- and trichloro-acetates methyl, n-propyl, n-octyl and n-dodecyl propionates ethyl butyrate n-butyl and n-amyl valerates ethyl laurate ethyl lactate ethyl acetoacetate diethyl carbonate dimethyl and diethyl oxalates diethyl malonate diethyl adipate di-n-butyl tartrate ethyl phenylacetate methyl and ethyl benzoates methyl and ethyl salicylates diethyl and di-n-butyl phthalates. The method fails for vinyl acetate, ieri.-butyl acetate, n-octadecyl propionate, ethyl and >i-butyl stearate, phenyl, benzyl- and guaicol-acetate, methyl and ethyl cinnamate, diethyl sulphate and ethyl p-aminobenzoate. 

Figure22.5 Reaction of (/ ,S)-metoprolol with (S)-fezr-butyl 3-(chloroformoxy)-butyrate and determination of the ratio of enantiomers in human plasma (reproduced with permission from A. Green, S. Chen, U. Skantze, I. Grundevik and M. Ahnoff, poster at the 13th International Symposium on Column Liquid Chromatography, Stockholm, 1989.) Conditions stationary phase, octadecyl silica mobile phase, phosphate buffer-acetonitrile (1 1) fluorescence detector 272/312 nm.

C22H37F7O2 2,2,33,4,4,4-heptafluoro-butyric acid octadecyl ester 400-57-7... 

---