Observed organism interactions, aspects

After separating steric effect by the STERIMOL term, the slope of the ct° terms in Eq. 40 and 41 is close to those observed for the same type of acylation reactions in a number of physical organic systems37>. Thus, STERIMOL values can well be used as free-energy-related parameters in combination with ct and parameters and provide informations about three-dimensional aspects of the interactions between drugs and biomolecules. 

Hence, for example, Dollimore etal have considered thermodynamic aspects of the adsorption of organic vapours on graphites and carbon blacks. Heats of adsorption and entropies of adsorbed vapours were determined, and the authors came to the conclusion that mobile adsorption appeared to be very important in the systems. In some ways the observation that C2-C4 hydrocarbons were adsorbed flat on a graphite surface tends to support this conclusion, although Hoory and Praunitz prefer to explain their results in terms of double bond interaction with the graphite.Jonas et al. find... 

Metabolic, nutritional and toxicological aspects of 160-163 Se were studied. The transport of Se within the organism and the urine metabolites observed were different, depending on the form of Se administred. Rapid and efficient incorporation of Se into SeP in the liver and excretion into the plasma followed by the slow and steady incorporation of Se into GPx in the kidneys and excretion into the plasma described. The formation of Se-methyl-/V-acetylselenohexosa-mine in liver and its excretion via urine were reported. The mechanisms underlying the interaction between Se and mercuric ions in the bloodstream were explained by the formation of a ternary complex, [(HgSe) ], -selenoprotein P... 

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